Functions of Dr. PRP

PRP Growth Factors
PRP contains growth factors that stimulate cellular growth and division. (Click plus signs below to read more)

TGF-B (Transforming Growth Factor-beta)

Platelets. extracellular matrix of bone. cartilage matrix, activated TH1 cells and natural killer cells, macrephages/monocytes and neutrophils

Stimulates undifferentiated mesenchymal cell proliferation. regulates endothelial, fibroblastic and osteobIastic mitogenesis: regulates collagen synthesis and collagenase secretion: regulates mitogenic effects of other growth factors; stimulates endothelial chemotaxis and angiogenesis: inhibits macrophage and lymphocyte proliferation

bGFG (Basic Fibroblast Growth Factor)

SourcePlatelets. macrophages. mesenchymal cells. chondrecytes. osteoblasts

FunctionPromotes growth and differentiation of chondrecytes and osteoblasts. mitogenetic for mesenchymal cells. chondrocytes and osteoblasts

PDGFa-b (Platelet Derived Growth Factor)

Platelets, osteoblasts, endothelial cells, macrophages, monocytes, smooth muscle cells

FunctionMitogenetic for mesenchymal cells and osteoblasts. stimulates chemotaxis and mitogenesis in fibroblasts/glia/smooth muscle cells. Regulates collagenasa secretion and collagen synthesis: stimulates macrophage and neutrophil chemotaxis

EGF (Epidermal Growth Factor)

SourcePlatelets, macrophages. monocytes

FunctionStimulates endothelial chemotaxis/angiogenesis regulates collagenase secretion: stimulates epithelial/mesenchymal mitogenesis

VEGF (Vascular Endothelial Growth Factor)

Source Platelets. endothelial cellsFunction
Increases angiogenesis and vessel permeability. stimulates mitogenesis for endothelial cells

CTGF (Connective Tissue Growth Factor)

Platelets, through endocytosis from extracellular environment in bone marrow

Promotes angiogenesis cartilage regeneration, fibrosis and platelet adhesion