PRP Growth Factors

PRP (Platelet-rich plasma) contains growth factors that stimulate cellular growth and division.

TGF-B
(Transforming Growth Factor-beta)
tgf-b-protein-extract

Source
Platelets. extracellular matrix of bone. cartilage matrix, activated TH1 cells and natural killer cells, macrephages/monocytes and neutrophils

Function
Stimulates undifferentiated mesenchymal cell proliferation. regulates endothelial, fibroblastic and osteobIastic mitogenesis: regulates collagen synthesis and collagenase secretion: regulates mitogenic effects of other growth factors; stimulates endothelial chemotaxis and angiogenesis: inhibits macrophage and lymphocyte proliferation

bGFG
(Basic Fibroblast Growth Factor)
250px-protein_fgf2_pdb_1bas

Source
Platelets. macrophages. mesenchymal cells. chondrecytes. osteoblasts

Function
Promotes growth and differentiation of chondrecytes and osteoblasts. mitogenetic for mesenchymal cells. chondrocytes and osteoblasts

PDGFa-b (Platelet Derived Growth Factor)

platelet-derived-growth-factor

Source
Platelets, osteoblasts, endothelial cells, macrophages, monocytes, smooth muscle cells

Function
Mitogenetic for mesenchymal cells and osteoblasts. stimulates chemotaxis and mitogenesis in fibroblasts/glia/smooth muscle cells. Regulates collagenasa secretion and collagen synthesis: stimulates macrophage and neutrophil chemotaxis

EGF (Epidermal Growth Factor)

epidermal-growth-factor

Source
Platelets, macrophages. monocytesFunction

Stimulates endothelial chemotaxis/angiogenesis regulates collagenase secretion: stimulates epithelial/mesenchymal mitogenesis

VEGF (Vascular Endothelial Growth Factor)

epidermal-growth-factor

Source
Platelets. endothelial cells

Function
Increases angiogenesis and vessel permeability. stimulates mitogenesis for endothelial cells

CTGF (Connective Tissue Growth Factor)

connective-tissue-growth-factor-ctgf

Source
Platelets, through endocytosis from extracellular environment in bone marrow

Function
Promotes angiogenesis cartilage regeneration, fibrosis and platelet adhesion